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Systemic Anti-Cancer Therapy Regimen Library

Home > BR Adjuvant - olaparib

BR Adjuvant - olaparib

Treatment Overview

Continuous for up to 1 year, or until disease progression or unacceptable toxicity.

Cycles 1 to 13 - 28 days

Cycle length:
28

Cycle details

Cycles 1 to 13 - 28 days

Medication Dose Route Days Max Duration
olaparib 300 mg Twice daily oral administration 1 to 28
domperidone 10 mg Three times daily oral administration 1

Full details

Cycles 1 to 13 - 28 days

Day: 1

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).
domperidone 10 mg Three times daily oral administration
Instructions:

When required for nausea and/or vomiting.

  • The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics.

Day: 2

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 3

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 4

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 5

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 6

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 7

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 8

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 9

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 10

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 11

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 12

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 13

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 14

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 15

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 16

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 17

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 18

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 19

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 20

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 21

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 22

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 23

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 24

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 25

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 26

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 27

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Day: 28

Medication Dose Route Max duration Details
olaparib 300 mg Twice daily oral administration
Instructions:
Swallow whole, do not crush or chew. Avoid food containing grapefruit or Seville oranges during treatment. May affect performance of skilled tasks (e.g. driving).

Supportive Care Factors

Factor Value
Emetogenicity: Medium to high

Emetogenicity: Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.

References

Robson, M. E., N. Tung, P. Conte, et al. 2019. "OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer." Ann Oncol 30(4):558-566., PMID: 30689707

Senkus E, Delaloge S, Domchek SM, Conte P, Im SA, Xu B, Armstrong A, Masuda N, Fielding A, Robson M, Tung N. Olaparib efficacy in patients with germline BRCA-mutated, HER2-negative metastatic breast cancer: Subgroup analyses from the phase III OlympiAD trial. Int J Cancer. 2023 Aug 15;153(4):803-814. doi: 10.1002/ijc.34525. Epub 2023 Apr 6., PMID: 36971103

AstraZeneca Limited. Lynparza Tablets Medsafe Data Sheet 19 June 2023. https://www.medsafe.govt.nz/profs/Datasheet/l/lynparzatab.pdf (Accessed 23 September 2023)

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.