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Systemic Anti-Cancer Therapy Regimen Library

Haematopoietic Stem Cell Transplant Regimens


Haematology regimens within the SACT Regimen Library currently only specify mandatory supportive care medicines to be used for all patients, unless contraindicated. A clinically equivalent mandatory medicine may be substituted as per institutional practice.

Supportive care factors are included in all regimens, with the appropriate dimensions (value) as Recommended (for most patients), Consider (for some patients after clinical risk assessment), or with guidance (e.g. emetogenicity classification or if variable). Centres are expected to include antiemetics and other supportive care medicines within their own prescribing systems.


Allogeneic conditioning Regimens


Published

Name Version Date
HSCT Allogeneic conditioning Myeloablative Haploidentical - Flu/Bu4 with PTCy [fludarabine and busulfan with post-transplant CYCLOPHOSPHamide]1.0.028/11/2024
HSCT Allogeneic conditioning Myeloablative Haploidentical - Flu/TBI 8Gy with PTCy [fludarabine and total body irradiation 8Gy with post-transplant CYCLOPHOSPHamide]1.0.023/01/2025
HSCT Allogeneic conditioning Myeloablative Matched unrelated donor - Bu/Cy/ATG [busulfan, CYCLOPHOSPHamide and Thymoglobuline]1.0.028/11/2024
HSCT Allogeneic conditioning Myeloablative Matched unrelated donor - Cy/Bu/ATG [CYCLOPHOSPHamide, busulfan and Thymoglobuline] [reversed order]1.0.023/01/2025
HSCT Allogeneic conditioning Myeloablative Matched unrelated donor - Cy/TBI2/ATG [CYCLOPHOSPHamide followed by total body irradiation and Thymoglobuline] [2 day]1.0.023/01/2025
HSCT Allogeneic conditioning Myeloablative Matched unrelated donor - Cy/TBI3/ATG [CYCLOPHOSPHamide followed by total body irradiation and Thymoglobuline] [3 day]1.0.023/01/2025
HSCT Allogeneic conditioning Myeloablative Matched unrelated donor - Flu/Bu4/ATG [fludarabine, busulfan, and Thymoglobuline]1.0.028/11/2024
HSCT Allogeneic conditioning Myeloablative Sibling - Bu/Cy [busulfan and CYCLOPHOSPHamide]1.0.028/11/2024
HSCT Allogeneic conditioning Myeloablative Sibling - Cy/Bu [CYCLOPHOSPHamide and busulfan] [reversed order]1.0.023/01/2025
HSCT Allogeneic conditioning Myeloablative Sibling - Cy/TBI [CYCLOPHOSPHamide followed by total body irradiation]1.0.023/01/2025
HSCT Allogeneic conditioning Myeloablative Sibling - Flu/Bu4 [fludarabine and busulfan]1.0.028/11/2024
HSCT Allogeneic conditioning Myeloablative Sibling - TBI/Cy [total body irradiation followed by CYCLOPHOSPHamide]1.0.023/01/2025
HSCT Allogeneic conditioning Myeloablative Sibling - total body irradiation followed by CYCLOPHOSPHamide [UKALL14]1.0.023/01/2025
HSCT Allogeneic conditioning Non–myeloablative - Flu/TBI 2Gy [fludarabine and low dose total body irradiation 2Gy]1.0.023/01/2025
HSCT Allogeneic conditioning Reduced intensity Haploidentical - Flu/Bu3 with PTCy [fludarabine and busulfan with post-transplant CYCLOPHOSPHamide]1.0.023/01/2025
HSCT Allogeneic conditioning Reduced intensity Haploidentical - Flu/Cy/TBI 2Gy with PTCy [fludarabine, CYCLOPHOSPHamide and total body irradiation 2Gy with post-transplant CYCLOPHOSPHamide]1.0.023/01/2025
HSCT Allogeneic conditioning Reduced intensity Haploidentical - Mel/Flu/TBI 2Gy with PTCy [melphalan, fludarabine and total body irradiation 2Gy with post-transplant CYCLOPHOSPHamide]1.0.023/01/2025
HSCT Allogeneic conditioning Reduced intensity Matched unrelated donor - Flu/Bu2/ATG [fludarabine, busulfan, and Thymoglobuline]1.0.028/11/2024
HSCT Allogeneic conditioning Reduced intensity Matched unrelated donor - Flu/Bu3/ATG [fludarabine, busulfan and Thymoglobuline]1.0.023/01/2025
HSCT Allogeneic conditioning Reduced intensity Matched unrelated donor - Flu/Mel/ATG [fludarabine, melphalan and Thymoglobuline]1.0.023/01/2025
HSCT Allogeneic conditioning Reduced intensity Sibling - Flu/Bu2 [fludarabine and busulfan]1.0.028/11/2024
HSCT Allogeneic conditioning Reduced intensity Sibling - Flu/Bu3 [fludarabine and busulfan]1.0.028/11/2024
HSCT Allogeneic conditioning Reduced intensity Sibling - Flu/Mel [fludarabine and melphalan]1.0.028/11/2024

Mobilisation Regimens


Published

Name Version Date
HSCT Mobilisation - CYCLOPHOSPHamide and filgrastim1.0.028/11/2024
HSCT Mobilisation - filgrastim1.0.028/11/2024
HSCT Mobilisation - filgrastim and plerixafor1.0.028/11/2024