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Systemic Anti-Cancer Therapy Regimen Library

Home > BR Adjuvant - exemestane and goserelin

BR Adjuvant - exemestane and goserelin

Treatment Overview

Continuous for up to 5 years. Exemestane may be continued for a further 5 years after completion of 5 years in combination with goserelin.

Cycle 1 (and all further cycles) - 28 days

Cycle length:
28

Consider oral supplementation of at least 500 mg elemental calcium daily and vitamin D equivalent to 400 units daily (e.g. colecalciferol 1.25 mg orally ONCE a month) for the duration of treatment.

Cycle details

Cycle 1 (and all further cycles) - 28 days

Medication Dose Route Days Max Duration
goserelin 3.6 mg subcutaneous injection 1
exemestane * 25 mg Once daily oral administration 1 to 28

Consider oral supplementation of at least 500 mg elemental calcium daily and vitamin D equivalent to 400 units daily (e.g. colecalciferol 1.25 mg orally ONCE a month) for the duration of treatment.

Full details

Cycle 1 (and all further cycles) - 28 days

Day: 1

Medication Dose Route Max duration Details
goserelin 3.6 mg subcutaneous injection
Instructions:
Consider oral supplementation of at least 500 mg elemental calcium daily and vitamin D equivalent to 400 units daily (e.g. colecalciferol 1.25 mg orally ONCE a month) for the duration of treatment.
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 2

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 3

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 4

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 5

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 6

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 7

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 8

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 9

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 10

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 11

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 12

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 13

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 14

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 15

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 16

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 17

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 18

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 19

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 20

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 21

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 22

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 23

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 24

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 25

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 26

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 27

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Day: 28

Medication Dose Route Max duration Details
exemestane * 25 mg Once daily oral administration
Instructions:
Take with food.

Supportive Care Factors

No supportive care factors specified

References

1. Pagani, O., M. M. Regan, B. A. Walley, et al. 2014. "Adjuvant exemestane with ovarian suppression in premenopausal breast cancer." N Engl J Med 371(2):107-118, PMID: 24881463

2. Francis, P. A., O. Pagani, G. F. Fleming, et al. 2018. "Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer." N Engl J Med 379(2):122-137, PMID: 29863451

3. Francis, P. A., M. M. Regan, G. F. Fleming, et al. 2015. "Adjuvant ovarian suppression in premenopausal breast cancer." N Engl J Med 372(5):436-446, PMID: 25495490

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.