Systemic Anti-Cancer Therapy Regimen Library
GYN OV Recurrent - etoposide oral
Treatment Overview
Escalate dose intensity as tolerated; proceed to longer etoposide course only if previous cycle was well tolerated with no toxicity.
Cycle 1 - 21 days - etoposide days 1 to 7
Proceed to longer etoposide course (Cycle 2) only if well tolerated and no toxicity.
Emetogenicity: MEDIUM to HIGH—Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.
Cycle 2 - 21 days - etoposide days 1 to 10
Proceed to longer etoposide course (Cycle 3) only if previous cycle tolerated and no toxicity.
Emetogenicity: MEDIUM to HIGH—Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.
Cycle 3 (and all further cycles) - 21 days - etoposide days 1 to 14
Emetogenicity: MEDIUM to HIGH—Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.
Cycle details
Cycle 1 - 21 days - etoposide days 1 to 7
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration | 1 to 7 | |
| domperidone | 10 mg Three times daily | oral administration | 1 |
Proceed to longer etoposide course (Cycle 2) only if well tolerated and no toxicity.
Emetogenicity: MEDIUM to HIGH—Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.
Cycle 2 - 21 days - etoposide days 1 to 10
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration | 1 to 10 | |
| domperidone | 10 mg Three times daily | oral administration | 1 |
Proceed to longer etoposide course (Cycle 3) only if previous cycle tolerated and no toxicity.
Emetogenicity: MEDIUM to HIGH—Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.
Cycle 3 (and all further cycles) - 21 days - etoposide days 1 to 14
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration | 1 to 14 | |
| domperidone | 10 mg Three times daily | oral administration | 1 |
Emetogenicity: MEDIUM to HIGH—Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.
Full details
Cycle 1 - 21 days - etoposide days 1 to 7
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
|
| domperidone | 10 mg Three times daily | oral administration |
Instructions:
When required for nausea and/or vomiting. The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Cycle 2 - 21 days - etoposide days 1 to 10
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
|
| domperidone | 10 mg Three times daily | oral administration |
Instructions:
When required for nausea and/or vomiting. The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 8
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 9
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 10
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Cycle 3 (and all further cycles) - 21 days - etoposide days 1 to 14
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
|
| domperidone | 10 mg Three times daily | oral administration |
Instructions:
When required for nausea and/or vomiting. The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 8
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 9
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 10
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 11
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 12
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 13
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Day: 14
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| etoposide * | 50 mg flat dosing Once daily | oral administration |
Instructions:
Take each dose on an empty stomach - one hour before OR two hours after food. Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist. |
Supportive Care Factors
| Factor | Value |
|---|---|
| Emetogenicity: | Medium to high |
References
* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.