Menu Close Menu

Fewer cancers.
Better survival.
Equity for all.

Systemic Anti-Cancer Therapy Regimen Library

HSCT Allogeneic conditioning Non–myeloablative - Flu/TBI 2Gy [fludarabine and low dose total body irradiation 2Gy]

Treatment Overview

Cycle 1 - 180 days

Cycle length:
180

Hydration is recommended as per institutional practice and may need an individualised approach.


ciclosPORIN:

  • Adjust dose according to trough levels and to avoid toxicity until Day 90, as per institutional practice.
  • Then taper dose through until Day 180, as per institutional practice.

mycophenolate mofetil:

  • Commence first dose in the afternoon of Day 0.
  • After Day 27 taper dose as determined by patient factors as per institutional practice.

Cycle details

Cycle 1 - 180 days

Medication / Procedure Dose Route Days Max Duration
fludarabine * 30 mg/m² Once daily intravenous -4, -3, -2 30 minutes
ciclosPORIN 2 mg/kg Twice daily oral administration -4 to 90
Total body irradiation 2 Gy 0
paracetamol * 1000 mg flat dosing oral administration 0
proMETHazine * 12.5 mg intravenous 0 1 minutes
Allogeneic stem cell transplant intravenous 0
mycophenolate mofetil * 15 mg/kg Twice daily oral administration 0 to 27
mycophenolate mofetil * [Dose - see details] oral administration 28 to 90
ciclosPORIN [Dose - see details] Twice daily oral administration 91 to 180

Hydration is recommended as per institutional practice and may need an individualised approach.


ciclosPORIN:

  • Adjust dose according to trough levels and to avoid toxicity until Day 90, as per institutional practice.
  • Then taper dose through until Day 180, as per institutional practice.

mycophenolate mofetil:

  • Commence first dose in the afternoon of Day 0.
  • After Day 27 taper dose as determined by patient factors as per institutional practice.

Full details

Cycle 1 - 180 days

Day: -4

Medication Dose Route Max duration Details
fludarabine * 30 mg/m² Once daily intravenous 30 minutes Additional details:
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: -3

Medication Dose Route Max duration Details
fludarabine * 30 mg/m² Once daily intravenous 30 minutes Additional details:
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: -2

Medication Dose Route Max duration Details
fludarabine * 30 mg/m² Once daily intravenous 30 minutes Additional details:
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: -1

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 0

Medication / Procedure Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Total body irradiation 2 Gy
Instructions:
  • Administer as one fraction prior to allogeneic stem cell infusion.
  • Dose of total body irradiation must finish no later than 60 minutes prior to stem cell infusion. 
  • Or as per institutional practice.
paracetamol * 1000 mg flat dosing oral administration
Instructions:

ONE hour prior to return of allogeneic stem cells, or as per institutional practice.

proMETHazine * 12.5 mg intravenous 1 minutes
Instructions:

ONE hour prior to return of allogeneic stem cells, or as per institutional practice.

Allogeneic stem cell transplant intravenous
Instructions:

Administer as per institutional practice.

mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Commence in the afternoon of Day 0.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 1

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 2

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 3

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 4

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 5

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 6

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 7

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 8

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 9

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 10

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 11

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 12

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 13

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 14

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 15

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 16

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 17

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 18

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 19

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 20

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 21

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 22

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 23

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 24

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 25

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 26

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 27

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * 15 mg/kg Twice daily oral administration
Instructions:

After Day 27 taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 28

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 29

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 30

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 31

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 32

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 33

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 34

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 35

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 36

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 37

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 38

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 39

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 40

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 41

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 42

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 43

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 44

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 45

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 46

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 47

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 48

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 49

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 50

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 51

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 52

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 53

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 54

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 55

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 56

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 57

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 58

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 59

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 60

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 61

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 62

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 63

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 64

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 65

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 66

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 67

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 68

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 69

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 70

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 71

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 72

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 73

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 74

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 75

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 76

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 77

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 78

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 79

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 80

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 81

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 82

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 83

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 84

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 85

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 86

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 87

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 88

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 89

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough levels and to avoid toxicity as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 90

Medication Dose Route Max duration Details
ciclosPORIN 2 mg/kg Twice daily oral administration
Instructions:

Every 12 hours.

  • Adjust dose according to trough level and to avoid toxicity until Day 90, then taper dose through until Day 180, or as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
mycophenolate mofetil * [Dose - see details] oral administration
Instructions:

Taper dose as determined by patient factors as per institutional practice.

  • Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine.

Day: 91

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 92

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 93

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 94

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 95

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 96

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 97

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 98

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 99

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 100

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 101

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 102

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 103

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 104

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 105

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 106

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 107

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 108

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 109

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 110

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 111

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 112

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 113

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 114

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 115

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 116

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 117

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 118

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 119

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 120

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 121

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 122

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 123

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 124

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 125

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 126

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 127

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 128

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 129

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 130

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 131

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 132

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 133

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 134

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 135

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 136

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 137

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 138

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 139

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 140

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 141

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 142

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 143

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 144

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 145

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 146

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 147

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 148

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 149

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 150

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 151

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 152

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 153

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 154

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 155

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 156

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 157

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 158

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 159

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 160

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 161

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 162

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 163

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 164

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 165

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 166

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 167

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 168

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 169

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 170

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 171

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 172

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 173

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 174

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 175

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 176

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 177

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 178

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 179

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Day: 180

Medication Dose Route Max duration Details
ciclosPORIN [Dose - see details] Twice daily oral administration
Instructions:

Every 12 hours.

  • Taper dose as determined by patient factors as per institutional practice.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.


Additional details

Section 1: Dosing for bodyweight

Supportive Care Factors

Factor Value
Antifungal prophylaxis: Routine antifungal prophylaxis recommended
Antiviral prophylaxis for hepatitis B virus: Required for anti–HBc positive patients at risk of reactivation
Antiviral prophylaxis for herpes virus: Routine antiviral prophylaxis recommended
CMV monitoring: Recommended
Emetogenicity: Variable
Gastroprotection: Gastroprotection may be considered
Graft versus host disease prophylaxis: Graft versus host disease prophylaxis is mandatory
Hydration: Routine hydration recommended
Hypersensitivity / Infusion related reaction risk: High - routine premedication recommended
Irradiated blood components: Irradiation of blood components is recommended
Pneumocystis jirovecii pneumonia (PJP) prophylaxis: Routine antibiotic prophylaxis recommended
Sinusoidal obstruction syndrome prophylaxis: Sinsuoidal obstruction prophylaxis may be considered
Tumour lysis syndrome prophylaxis: Tumour lysis syndrome prophylaxis may be considered

Antifungal prophylaxis: Inhibition of CYP3A4 by azole antifungals will lead to reduced ciclosPORIN clearance and increased toxicities. A reduced ciclosPORIN dose is required with close monitoring of ciclosPORIN levels—see prescribing information, or Interactions checker in the NZ Formulary (nzf.org.nz).


CMV monitoring:

  • If allograft recipient +/- donor are CMV seropositive:
  • CMV quantitative PCR monitoring of CMV viral load should commence day 14 and be repeated once a week.
  • Evidence of CMV reactivation necessitates appropriate antiviral treatment. 

Emetogenicity:

  • MINIMAL days -4, -3, and -2;
  • Radiotherapy-induced nausea and vomiting (RINV) day 0.

References

Niederwieser, D., M. Maris, J. A. Shizuru, et al. 2003. "Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases." Blood 101(4):1620-1629. , PMID: 12393457

Kerbauy, F. R., R. Storb, U. Hegenbart, et al. 2005. "Hematopoietic cell transplantation from HLA-identical sibling donors after low-dose radiation-based conditioning for treatment of CML." Leukemia 19(6):990-997. , PMID: 15800667

Hegenbart, U., D. Niederwieser, B. M. Sandmaier, et al. 2006. "Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors." J Clin Oncol 24(3):444-453., PMID: 16344316

Baron, F., P.Zachee, J.Maertens, et al. 2015. "Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society". J Hematol Oncol 8(4): 1-8., PMID: 25652604

Kornblit, B., D. G. Maloney, R. Storb, et al. 2013. "Fludarabine and 2-Gy TBI is superior to 2 Gy TBI as conditioning for HLA-matched related hematopoietic cell transplantation: a phase III randomized trial." Biol Blood Marrow Transplant 19(9):1340-1347. , PMID: 23769990

Blaise, D., R. Tabrizi, J. M. Boher, et al. 2013. "Randomized study of 2 reduced-intensity conditioning strategies for human leukocyte antigen-matched, related allogeneic peripheral blood stem cell transplantation: prospective clinical and socioeconomic evaluation." Cancer 119(3):602-611. , PMID: 22893313

Cable, C., M. P. Buzzeo, J. D. Schold, et al. 2010. "Reduced-intensity conditioning using fludarabine with either antithymocyte globulin and BU, or low-dose TBI allowing allogeneic hematopoietic SCT." Bone Marrow Transplant 45(1):31-37., PMID: 19543325

Delgado, J. A. Marco, E. Moreno et al. 2009. "Reduced-intensity conditioning allogeneic hematopoietic cell transplantation using oral fludarabine as part of the conditioning regimen." Cytotherapy 11(3):356-61., PMID: 19148841

von dem Borne, P.A., C.W. Starrenburg, R.M. Barge et al. 2008. "Comparable engraftment and chimerism kinetics using oral and intravenous fludarabine as part of a reduced intensity conditioning regimen." Bone Marrow Transplant. 42(2):137-8., PMID: 18425146

Velázquez-Sánchez-de-Cima, S., G. Zamora-Ortiz, J. Hernández-Reyes et al. 2014. "Oral versus Intravenous Fludarabine as Part of a Reduced-Intensity Conditioning for Allogeneic Stem Cell Transplantation." Acta Haematol. 132(1):125-8., PMID: 24556580

Gifford, G., K. Wong, I. Kerridge et al. 2015. "Addition of low dose total body irradiation to fludarabine melphalan reduced intensity conditioning is feasible, tolerable, and may improve outcomes in patients with high-risk acute myeloid leukaemia and other high risk myeloid malignancies." Am J Hematol. 90(5):E97-100., PMID: 25683457

Nair, A.P., P. Walker, A. Kalff et al. 2017. "Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma." Bone Marrow Transplant. 52(6):839-845., PMID: 28319080

Lwin, Y., J. Lindsay, C. Reid et al. 2020. "Oral fludarabine is an effective and convenient alternative to intravenous fludarabine in fludarabine melphalan based reduced intensity conditioning regimens." Bone Marrow Transplant. 55(8):1638-1641., PMID: 31591449

Bubalo J, Carpenter PA, et al; American Society for Blood and Marrow Transplantation practice guideline committee. Conditioning chemotherapy dose adjustment in obese patients: a review and position statement by the American Society for Blood and Marrow Transplantation practice guideline committee. Biol Blood Marrow Transplant. 2014 May;20(5):600-16. doi: 10.1016/j.bbmt.2014.01.019. Epub 2014 Jan 23., PMID: 24462742

New Zealand Blood Service Transfusion Medicine Handbook Third Edition, 2016 https://www.nzblood.co.nz/assets/Transfusion-Medicine/PDFs/111G122.pdf (accessed 16 June 2022).

Doyle J, Raggatt M, Slavin M, McLachlan SA, Strasser SI, Sasadeusz JJ, Howell J, Hajkowicz K, Nandurkar H, Johnston A, Bak N, Thompson AJ. Hepatitis B management during immunosuppression for haematological and solid organ malignancies: an Australian consensus statement. Med J Aust. 2019 Jun;210(10):462-468. doi: 10.5694/mja2.50160. Epub 2019 May 19., PMID: 31104328

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.