Systemic Anti-Cancer Therapy Regimen Library
LEU CLL - venetoclax
Treatment Overview
Cycle 1 - 35 days - Titration phase weeks 1 to 5
Cycle length:
35
venetoclax: Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.
Cycle 2 (and all further cycles) - 28 days - Week 6 onwards
Cycle length:
28
Cycle details
Cycle 1 - 35 days - Titration phase weeks 1 to 5
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration | -3 to 35 | |
| venetoclax | 20 mg Once daily | oral administration | 1 to 7 | |
| venetoclax | 50 mg Once daily | oral administration | 8 to 14 | |
| venetoclax | 100 mg Once daily | oral administration | 15 to 21 | |
| venetoclax | 200 mg Once daily | oral administration | 22 to 28 | |
| venetoclax | 400 mg Once daily | oral administration | 29 to 35 |
venetoclax: Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.
Cycle 2 (and all further cycles) - 28 days - Week 6 onwards
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration | 1 to 28 |
Full details
Cycle 1 - 35 days - Titration phase weeks 1 to 5
Day: -3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
Day: -2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
Day: -1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
Day: 0
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 20 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 20 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 20 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 20 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 20 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 20 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 20 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 8
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 50 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 9
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 50 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 10
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 50 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 11
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 50 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 12
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 50 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 13
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 50 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 14
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 50 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 15
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 100 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 16
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 100 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 17
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 100 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 18
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 100 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 19
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 100 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 20
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 100 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 21
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 100 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 22
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 200 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 23
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 200 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 24
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 200 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 25
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 200 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 26
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 200 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 27
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 200 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 28
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 200 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 29
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 30
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 31
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 32
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 33
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 34
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 35
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| aLLOPURINol | 300 mg Once daily | oral administration |
Instructions:
Take with food. |
|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Cycle 2 (and all further cycles) - 28 days - Week 6 onwards
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 8
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 9
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 10
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 11
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 12
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 13
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 14
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 15
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 16
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 17
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 18
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 19
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 20
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 21
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 22
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 23
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 24
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 25
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 26
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 27
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Day: 28
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| venetoclax | 400 mg Once daily | oral administration |
Instructions:
Take with food and a large glass of water. Swallow tablets whole, do not crush or chew. Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist. |
Supportive Care Factors
| Factor | Value |
|---|---|
| Antiviral prophylaxis for herpes virus: | Routine antiviral prophylaxis may be considered |
| Emetogenicity: | Minimal to low |
| Pneumocystis jirovecii pneumonia (PJP) prophylaxis: | Routine antibiotic prophylaxis may be considered |
| Tumour lysis syndrome prophylaxis: | Tumour lysis syndrome prophylaxis is mandatory |
Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.
Tumour lysis syndrome prophylaxis: Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.
References
AbbVie Venclexta New Zealand data sheet 01 February 2021 https://www.medsafe.govt.nz/profs/datasheet/v/venclextatab.pdf (accessed 15/6/2022).
* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.