Systemic Anti-Cancer Therapy Regimen Library
LEU APL - AIDA induction and consolidations 1, 2 and 3 [over 70 years]
Treatment Overview
This regimen is intended for those over 70 years.
It consists of 4 parts:
- Induction
- Consolidation 1
- Consolidation 2
- Consolidation 3.
Each part starts after count recovery from the previous part with:
- Neutrophils greater than 1.5 x 109/L and
- Platelets greater than 80 x 109/L.
Followed after count recovery by:
Followed after count recovery by:
Followed after count recovery by:
Supportive Care Factors
| Factor | Value |
|---|---|
| Antifungal prophylaxis: | Variable |
| Antiviral prophylaxis for herpes virus: | Routine antiviral prophylaxis recommended |
| Emetogenicity: | Variable |
| Tumour lysis syndrome prophylaxis: | Variable |
Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.
References
AML17 trial protocol Version 10.2 dated June 2019.
Baxter Healthcare Ltd ONKOTRONE Data sheet 22 October 2020 https://www.medsafe.govt.nz/profs/datasheet/o/Onkotroneinj.pdf (accessed 11 July 2022).
Pharmaco (NZ) Ltd Vesanoid® New Zealand data sheet 21 April 2022 https://www.medsafe.govt.nz/profs/datasheet/v/Vesanoidcap.pdf (accessed 15 July 2022).
Regimen details sometimes vary slightly from the published literature after recommendation by expert committee consensus.
* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.