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Systemic Anti-Cancer Therapy Regimen Library

Home > LEU CLL - ibrutinib and venetoclax

LEU CLL - ibrutinib and venetoclax

Treatment Overview

Ibrutinib has been associated with cardiac toxicities such as arrhythmias, hypertension, heart failure, and sudden cardiac death, particularly in patients with pre-existing cardiac disease factors. Consult product literature for recommendations.

Cycles 1 to 3 - 28 days - ibrutinib monotherapy

Cycle length:
28

Cycle 4 - 28 days - ibrutinib and venetoclax titration

Cycle length:
28

venetoclax: Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.

Cycle 5 - 28 days - ibrutinib and venetoclax maintenance dose

Cycle length:
28

venetoclax: Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.

Cycles 6 to 15 - 28 days - ibrutinib and venetoclax maintenance dose

Cycle length:
28

Cycle details

Cycles 1 to 3 - 28 days - ibrutinib monotherapy

Medication Dose Route Days Max Duration
ibrutinib 420 mg Once daily oral administration 1 to 28

Cycle 4 - 28 days - ibrutinib and venetoclax titration

Medication Dose Route Days Max Duration
aLLOPURINol 300 mg Once daily oral administration -3 to 28
ibrutinib 420 mg Once daily oral administration 1 to 28
venetoclax 20 mg Once daily oral administration 1 to 7
venetoclax 50 mg Once daily oral administration 8 to 14
venetoclax 100 mg Once daily oral administration 15 to 21
venetoclax 200 mg Once daily oral administration 22 to 28

venetoclax: Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.

Cycle 5 - 28 days - ibrutinib and venetoclax maintenance dose

Medication Dose Route Days Max Duration
aLLOPURINol 300 mg Once daily oral administration 1 to 7
ibrutinib 420 mg Once daily oral administration 1 to 28
venetoclax 400 mg Once daily oral administration 1 to 28

venetoclax: Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.

Cycles 6 to 15 - 28 days - ibrutinib and venetoclax maintenance dose

Medication Dose Route Days Max Duration
ibrutinib 420 mg Once daily oral administration 1 to 28
venetoclax 400 mg Once daily oral administration 1 to 28

Full details

Cycles 1 to 3 - 28 days - ibrutinib monotherapy

Day: 1

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 2

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 3

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 4

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 5

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 6

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 7

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 8

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 9

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 10

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 11

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 12

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 13

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 14

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 15

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 16

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 17

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 18

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 19

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 20

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 21

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 22

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 23

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 24

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 25

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 26

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 27

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Day: 28

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.

Cycle 4 - 28 days - ibrutinib and venetoclax titration

Day: -3

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.

Day: -2

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.

Day: -1

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.

Day: 0

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.

Day: 1

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 20 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 2

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 20 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 3

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 20 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 4

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 20 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 5

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 20 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 6

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 20 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 7

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 20 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 8

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 50 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 9

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 50 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 10

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 50 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 11

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 50 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 12

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 50 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 13

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 50 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 14

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 50 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 15

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 100 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 16

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 100 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 17

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 100 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 18

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 100 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 19

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 100 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 20

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 100 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 21

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 100 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 22

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 200 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 23

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 200 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 24

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 200 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 25

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 200 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 26

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 200 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 27

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 200 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 28

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 200 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Cycle 5 - 28 days - ibrutinib and venetoclax maintenance dose

Day: 1

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 2

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 3

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 4

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 5

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 6

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 7

Medication Dose Route Max duration Details
aLLOPURINol 300 mg Once daily oral administration
Instructions:

Take with food.
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 8

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 9

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 10

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 11

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 12

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 13

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 14

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 15

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 16

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 17

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 18

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 19

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 20

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 21

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 22

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 23

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 24

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 25

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 26

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 27

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 28

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Cycles 6 to 15 - 28 days - ibrutinib and venetoclax maintenance dose

Day: 1

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 2

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 3

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 4

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 5

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 6

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 7

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 8

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 9

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 10

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 11

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 12

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 13

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 14

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 15

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 16

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 17

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 18

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 19

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 20

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 21

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 22

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 23

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 24

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 25

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 26

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 27

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Day: 28

Medication Dose Route Max duration Details
ibrutinib 420 mg Once daily oral administration
Instructions:
  • Swallow capsules whole with a glass of water.
  • Avoid grapefruit or grapefruit juice and Seville oranges as they may interact with this medicine. Discuss with your pharmacist.
venetoclax 400 mg Once daily oral administration
Instructions:
  • Take with food and a large glass of water.
  • Swallow tablets whole, do not crush or chew.
  • Avoid foods containing grapefruit, starfruit or Seville oranges during treatment as they may interact with this medicine. Discuss with your pharmacist.

Supportive Care Factors

Factor Value
Antiviral prophylaxis for herpes virus: Routine antiviral prophylaxis recommended
Emetogenicity: Minimal to low
Pneumocystis jirovecii pneumonia (PJP) prophylaxis: Routine antibiotic prophylaxis may be considered
Tumour lysis syndrome prophylaxis: Variable

Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.


Tumour lysis syndrome (TLS) prophylaxis:

  • Cycle 1 (ibrutinib monotherapy): Consider TLS prophylaxis.
  • Cycles 4 and 5 (venetoclax initiation): Mandatory—Specific tumour lysis syndrome monitoring, hydration and dosing precautions apply to venetoclax dose titration. Consult product literature for details.

References

Kater AP, Owen C, Moreno C, et al. Fixed-Duration Ibrutinib-Venetoclax in Patients with Chronic Lymphocytic Leukemia and Comorbidities. NEJM Evid. 2022 Jul;1(7):EVIDoa2200006. , PMID: 38319255

Niemann CU, Munir T, Moreno C, et al. Fixed-duration ibrutinib-venetoclax versus chlorambucil-obinutuzumab in previously untreated chronic lymphocytic leukaemia (GLOW): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2023 Dec;24(12):1423-1433. , PMID: 37944541

Tam CS, Allan JN, Siddiqi T, et al. Fixed-duration ibrutinib plus venetoclax for first-line treatment of CLL: primary analysis of the CAPTIVATE FD cohort. Blood. 2022 Jun 2;139(22):3278-3289. , PMID: 35196370

AbbVie Limited. Venclexta New Zealand Data Sheet. 8 July 2024 https://www.medsafe.govt.nz/profs/datasheet/v/venclextatab.pdf (accessed 5 February 2026).

Janssen-Cilag (New Zealand) Ltd. Imbruvica New Zealand Data Sheet. 15 January 2025. https://www.medsafe.govt.nz/profs/datasheet/I/Imbruvicacap.pdf (accessed 5 February 2026).

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.