Systemic Anti-Cancer Therapy Regimen Library
LEU CLL - chlorambucil
Treatment Overview
Give until maximal improvement, progression or unacceptable toxicity. Maximum recommended duration of treatment using this regimen is up to 1 year.
Cycle 1 (and all further cycles) - 28 days
chlorambucil dose: Consider dose reduction of chlorambucil in patients with significant cytopenias, renal impairment, or low body weight.
Cycle details
Cycle 1 (and all further cycles) - 28 days
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration | 1 to 7 |
chlorambucil dose: Consider dose reduction of chlorambucil in patients with significant cytopenias, renal impairment, or low body weight.
Full details
Cycle 1 (and all further cycles) - 28 days
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration |
Instructions:
Always take at the same time in relation to food; preferably take at least one hour before or 3 hours after food, or take with food if significant gastric toxicity occurs. Consider dose reduction in patients with significant cytopenias, renal impairment, or low body weight. Round dose to closest multiple of 2 mg tablets. KEEP IN FRIDGE - DO NOT FREEZE. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration |
Instructions:
Always take at the same time in relation to food; preferably take at least one hour before or 3 hours after food, or take with food if significant gastric toxicity occurs. Consider dose reduction in patients with significant cytopenias, renal impairment, or low body weight. Round dose to closest multiple of 2 mg tablets. KEEP IN FRIDGE - DO NOT FREEZE. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration |
Instructions:
Always take at the same time in relation to food; preferably take at least one hour before or 3 hours after food, or take with food if significant gastric toxicity occurs. Consider dose reduction in patients with significant cytopenias, renal impairment, or low body weight. Round dose to closest multiple of 2 mg tablets. KEEP IN FRIDGE - DO NOT FREEZE. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration |
Instructions:
Always take at the same time in relation to food; preferably take at least one hour before or 3 hours after food, or take with food if significant gastric toxicity occurs. Consider dose reduction in patients with significant cytopenias, renal impairment, or low body weight. Round dose to closest multiple of 2 mg tablets. KEEP IN FRIDGE - DO NOT FREEZE. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration |
Instructions:
Always take at the same time in relation to food; preferably take at least one hour before or 3 hours after food, or take with food if significant gastric toxicity occurs. Consider dose reduction in patients with significant cytopenias, renal impairment, or low body weight. Round dose to closest multiple of 2 mg tablets. KEEP IN FRIDGE - DO NOT FREEZE. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration |
Instructions:
Always take at the same time in relation to food; preferably take at least one hour before or 3 hours after food, or take with food if significant gastric toxicity occurs. Consider dose reduction in patients with significant cytopenias, renal impairment, or low body weight. Round dose to closest multiple of 2 mg tablets. KEEP IN FRIDGE - DO NOT FREEZE. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| chlorambucil * | 10 mg/m² Once daily | oral administration |
Instructions:
Always take at the same time in relation to food; preferably take at least one hour before or 3 hours after food, or take with food if significant gastric toxicity occurs. Consider dose reduction in patients with significant cytopenias, renal impairment, or low body weight. Round dose to closest multiple of 2 mg tablets. KEEP IN FRIDGE - DO NOT FREEZE. |
Supportive Care Factors
| Factor | Value |
|---|---|
| Antiviral prophylaxis for herpes virus: | Routine antiviral prophylaxis may be considered |
| Emetogenicity: | Minimal to low |
| Tumour lysis syndrome prophylaxis: | Tumour lysis syndrome prophylaxis may be considered |
Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.
References
* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.