New Zealand Formulary
Menu Close Menu

Fewer cancers.
Better survival.
Equity for all.

Systemic Anti-Cancer Therapy Regimen Library

Home > LYM NHL B-cell MCL - ibrutinib

LYM NHL B-cell MCL - ibrutinib

Treatment Overview

Cycle 1 (and all further cycles) - 30 days

Cycle length:
30

Cycle details

Cycle 1 (and all further cycles) - 30 days

Medication Dose Route Days Max Duration
ibrutinib 560 mg Once daily oral administration 1 to 30

Full details

Cycle 1 (and all further cycles) - 30 days

Day: 1

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 2

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 3

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 4

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 5

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 6

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 7

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 8

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 9

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 10

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 11

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 12

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 13

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 14

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 15

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 16

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 17

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 18

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 19

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 20

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 21

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 22

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 23

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 24

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 25

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 26

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 27

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 28

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 29

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Day: 30

Medication Dose Route Max duration Details
ibrutinib 560 mg Once daily oral administration
Instructions:

Swallow capsules whole with a glass of water.

Avoid grapefruit or grapefruit juice as they may interact with this medicine. Discuss with your pharmacist.

Supportive Care Factors

Factor Value
Antifungal prophylaxis: Routine antifungal prophylaxis may be considered
Antiviral prophylaxis for herpes virus: Routine antiviral prophylaxis recommended
Emetogenicity: Minimal to low
Pneumocystis jiroveci pneumonia (PJP) prophylaxis: Routine antibiotic prophylaxis recommended
Tumour lysis syndrome prophylaxis: Tumour lysis syndrome prophylaxis may be considered

Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.

References

Wang ML, Blum KA, Martin P, Goy A, Auer R, Kahl BS, Jurczak W, Advani RH, Romaguera JE, Williams ME, Barrientos JC, Chmielowska E, Radford J, Stilgenbauer S, Dreyling M, Jedrzejczak WW, Johnson P, Spurgeon SE, Zhang L, Baher L, Cheng M, Lee D, Beaupre DM, Rule S. Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results. Blood. 2015 Aug 6;126(6):739-45. doi: 10.1182/blood-2015-03-635326. Epub 2015 Jun 9., PMID: 26059948

Dreyling M, Jurczak W, Jerkeman M, Silva RS, Rusconi C, Trneny M, Offner F, Caballero D, Joao C, Witzens-Harig M, Hess G, Bence-Bruckler I, Cho SG, Bothos J, Goldberg JD, Enny C, Traina S, Balasubramanian S, Bandyopadhyay N, Sun S, Vermeulen J, Rizo A, Rule S. Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study. Lancet. 2016 Feb 20;387(10020):770-8. doi: 10.1016/S0140-6736(15)00667-4. Epub 2015 Dec 7. Erratum in: Lancet. 2016 Feb 20;387(10020):750. , PMID: 26673811

Rule S, Jurczak W, Jerkeman M, Rusconi C, Trneny M, Offner F, Caballero D, Joao C, Witzens-Harig M, Hess G, Bence-Bruckler I, Cho SG, Thieblemont C, Zhou W, Henninger T, Goldberg J, Vermeulen J, Dreyling M. Ibrutinib versus temsirolimus: 3-year follow-up of patients with previously treated mantle cell lymphoma from the phase 3, international, randomized, open-label RAY study. Leukemia. 2018 Aug;32(8):1799-1803. doi: 10.1038/s41375-018-0023-2. Epub 2018 Feb 2., PMID: 29572505

Wang ML, Lee H, Chuang H, Wagner-Bartak N, Hagemeister F, Westin J, Fayad L, Samaniego F, Turturro F, Oki Y, Chen W, Badillo M, Nomie K, DeLa Rosa M, Zhao D, Lam L, Addison A, Zhang H, Young KH, Li S, Santos D, Medeiros LJ, Champlin R, Romaguera J, Zhang L. Ibrutinib in combination with Rituximab in relapsed or refractory mantle cell lymphoma: a single-centre, open-label, phase 2 trial. Lancet Oncol. 2016 Jan;17(1):48-56. doi: 10.1016/S1470-2045(15)00438-6. Epub 2015 Nov 28. , PMID: 26640039

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.