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Systemic Anti-Cancer Therapy Regimen Library

Home > LUNG NSCLC Locally advanced/Metastatic - alectinib

LUNG NSCLC Locally advanced/Metastatic - alectinib

Treatment Overview

Cycle 1 (and all further cycles) - 28 days

Cycle length:
28

Cycle details

Cycle 1 (and all further cycles) - 28 days

Medication Dose Route Days Max Duration
alectinib 600 mg Twice daily oral administration 1 to 28
loperamide 2 mg oral administration 1

Full details

Cycle 1 (and all further cycles) - 28 days

Day: 1

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.
loperamide 2 mg oral administration
Instructions:
Take TWO capsules (=4 mg) at onset of loose bowel motions and a further ONE capsule (=2 mg) for every loose bowel motion (maximum of EIGHT capsules in 24 hours), or use as directed by oncologist or haematologist.

Day: 2

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 3

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 4

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 5

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 6

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 7

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 8

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 9

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 10

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 11

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 12

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 13

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 14

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 15

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 16

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 17

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 18

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 19

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 20

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 21

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 22

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 23

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 24

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 25

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 26

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 27

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 28

Medication Dose Route Max duration Details
alectinib 600 mg Twice daily oral administration
Instructions:

Take with food.

Swallow whole, do not crush or chew.

Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Supportive Care Factors

Factor Value
Diarrhoea risk: Anti-diarrhoeals are usually prescribed with this treatment
Emetogenicity: Minimal to low

Emetogenicity: MINIMAL to LOW—Antiemetics may be required with continuous dosing of oral anti-cancer medicines with MINIMAL to LOW emetic risk; an individualised approach is appropriate. 

References

Mok, T., D. R. Camidge, S. M. Gadgeel, et al. 2020. "Updated overall survival and final progression-free survival data for patients with treatment-naive advanced ALK-positive non-small-cell lung cancer in the ALEX study." Ann Oncol 31(8):1056-1064., PMID: 32418886

Nakagawa, K., T. Hida, H. Nokihara, et al. 2020. "Final progression-free survival results from the J-ALEX study of alectinib versus crizotinib in ALK-positive non-small-cell lung cancer." Lung Cancer 139:195-199., PMID: 31812890

Peters, S., D. R. Camidge, A. T. Shaw, et al. 2017. "Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer." N Engl J Med 377(9):829-838., PMID: 28586279

Hida, T., H. Nokihara, M. Kondo et al. 2017. "Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial." Lancet 390(10089):29-39., PMID: 28501140

Camidge, D. R, Rafal D, Solange P, 2019. "Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of Alectinib in Untreated ALK-Positive Advanced Non–Small Cell Lung Cancer in the Global Phase III ALEX Study." Journal of Thoracic Oncology 14(7):1233-1243., PMID: 30902613

Roche Products (New Zealand) Limited. Alecensa New Zealand Data Sheet 31 August 2022. https://www.medsafe.govt.nz/profs/Datasheet/a/alecensacap.pdf (Accessed 23 July 2024).

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.