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Systemic Anti-Cancer Therapy Regimen Library

Home > UGI GIST Metastatic - ripretinib

UGI GIST Metastatic - ripretinib

Treatment Overview

Cycle 1 (and all further cycles) - 30 days

Cycle length:
30

Cycle details

Cycle 1 (and all further cycles) - 30 days

Medication Dose Route Days Max Duration
ripretinib 150 mg Once daily oral administration 1 to 30

Full details

Cycle 1 (and all further cycles) - 30 days

Day: 1

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 2

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 3

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 4

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 5

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 6

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 7

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 8

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 9

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 10

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 11

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 12

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 13

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 14

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 15

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 16

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 17

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 18

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 19

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 20

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 21

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 22

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 23

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 24

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 25

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 26

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 27

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 28

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 29

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 30

Medication Dose Route Max duration Details
ripretinib 150 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew.
  • Avoid grapefruit or grapefruit juice as they may interact with this medicine.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Supportive Care Factors

Factor Value
Constipation risk: Consider prescribing laxatives with this treatment
Diarrhoea risk: Consider prescribing antidiarrhoeals with this treatment
Emetogenicity: Minimal to low

Constipation/Diarrhoea risk: ripretinib may cause constipation or diarrhoea. Monitor gastrointestinal symptoms.


Emetogenicity: Antiemetics may be required with continuous dosing of oral anti-cancer medicines with MINIMAL to LOW emetic risk; an individualised approach is appropriate.

 

References

Blay JY, Serrano C, Heinrich MC, Zalcberg J, Bauer S, Gelderblom H, Schöffski P, Jones RL, Attia S, D'Amato G, Chi P, Reichardt P, Meade J, Shi K, Ruiz-Soto R, George S, von Mehren M. Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2020 Jul;21(7):923-934. doi: 10.1016/S1470-2045(20)30168-6. Epub 2020 Jun 5. Erratum in: Lancet Oncol. 2020 Jul;21(7):e341., PMID: 32511981

Bauer S, Jones RL, Blay JY et al. . Ripretinib Versus Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor After Treatment With Imatinib (INTRIGUE): A Randomized, Open-Label, Phase III Trial." J Clin Oncol. 2022 Dec; 40(34):3918-3928.

Specialised Therapeutics Limited. Qinlock New Zealand Datasheet 28 September 2023 https://www.medsafe.govt.nz/profs/datasheet/q/qinlocktab.pdf (Accessed 16 April 2024)

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.