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Systemic Anti-Cancer Therapy Regimen Library

Home > GU PROS Castration sensitive Metastatic - DOCEtaxel, abiraterone and prEDNISone

GU PROS Castration sensitive Metastatic - DOCEtaxel, abiraterone and prEDNISone

Treatment Overview

Cycle 1 (and all further cycles) - 21 days

Cycle length:
21

dexamethasone: Some centres may wish to replace the three oral doses of dexamethasone 8 mg premedication with a single intravenous dose of dexamethasone 20 mg prior to DOCEtaxel infusion.

Cycle details

Cycle 1 (and all further cycles) - 21 days

Medication Dose Route Days Max Duration
dexamethasone * 8 mg oral administration 0, 1
dexamethasone * 8 mg oral administration 1
DOCEtaxel * 75 mg/m² intravenous 1 60 minutes
abiraterone 1000 mg Once daily oral administration 1 to 21
prEDNISone * 5 mg flat dosing Once daily oral administration 1 to 21
domperidone 10 mg Three times daily oral administration 1
loperamide 2 mg oral administration 1

dexamethasone: Some centres may wish to replace the three oral doses of dexamethasone 8 mg premedication with a single intravenous dose of dexamethasone 20 mg prior to DOCEtaxel infusion.

Full details

Cycle 1 (and all further cycles) - 21 days

Day: 0

Medication Dose Route Max duration Details
dexamethasone * 8 mg oral administration
Instructions:

TWELVE hours prior to DOCEtaxel infusion with food.

Day: 1

Medication Dose Route Max duration Details
dexamethasone * 8 mg oral administration
Instructions:

THREE hours prior to DOCEtaxel infusion with food.
dexamethasone * 8 mg oral administration
Instructions:

ONE hour prior to DOCEtaxel infusion with food.
DOCEtaxel * 75 mg/m² intravenous 60 minutes
Instructions:
  • Prepare solution in PVC-free bag and administer via polyethylene lined administration set.
  • Please carry out graded challenge as per institutional policy.
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.
domperidone 10 mg Three times daily oral administration
Instructions:

When required for nausea and/or vomiting.

  • The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics.
loperamide 2 mg oral administration
Instructions:
Take TWO capsules (=4 mg) at onset of loose bowel motions and a further ONE capsule (=2 mg) for every loose bowel motion (maximum of EIGHT capsules in 24 hours), or use as directed by oncologist or haematologist.

Day: 2

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 3

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 4

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 5

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 6

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 7

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 8

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 9

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 10

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 11

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 12

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 13

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 14

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 15

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 16

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 17

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 18

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 19

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 20

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 21

Medication Dose Route Max duration Details
abiraterone 1000 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach - one hour before OR two hours after food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
prEDNISone * 5 mg flat dosing Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Supportive Care Factors

Factor Value
Diarrhoea risk: Anti-diarrhoeals are usually prescribed with this treatment
Emetogenicity: Low
Hypersensitivity / Infusion related reaction risk: High - routine premedication recommended

References

Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators. Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. Lancet. 2022 Apr 30;399(10336):1695-1707. doi: 10.1016/S0140-6736(22)00367-1. Epub 2022 Apr 8., PMID: 35405085

Janssen-Cilag (New Zealand) Limited. Zytga (abiraterone) Medsafe Data Sheet 17 November 2022. https://www.medsafe.govt.nz/profs/datasheet/z/zytigatab.pdf (Accessed 11 June 2024).

Pharmacy Retailing (NZ) Limited. Docetaxel Accord (Docetaxel) New Zealand Data Sheet 14 November 2023. https://www.medsafe.govt.nz/profs/datasheet/d/docetaxelaccordinj.pd (Accessed 11 June 2024).

Regimen details sometimes vary slightly from the published literature after recommendation by expert committee consensus.

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.