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Home > GU PROS Castration sensitive Metastatic - abiraterone micronised [Yonsa] and methylprednisolone

GU PROS Castration sensitive Metastatic - abiraterone micronised [Yonsa] and methylprednisolone

Treatment Overview

The dosing and administration in this regimen is for treatment with abiraterone micronised tablets (Yonsa®) only. Abiraterone is available as both conventional (e.g. Zytiga®) and micronised formulations; these are NOT interchangeable.

Cycle 1 (and all further cycles) - 30 days

Cycle length:
30

Cycle details

Cycle 1 (and all further cycles) - 30 days

Medication Dose Route Days Max Duration
abiraterone 500 mg Once daily oral administration 1 to 30
methylprednisolone 4 mg Once daily oral administration 1 to 30

Full details

Cycle 1 (and all further cycles) - 30 days

Day: 1

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 2

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 3

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 4

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 5

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 6

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 7

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 8

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 9

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 10

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 11

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 12

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 13

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 14

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 15

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 16

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 17

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 18

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 19

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 20

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 21

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 22

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 23

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 24

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 25

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 26

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 27

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 28

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 29

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Day: 30

Medication Dose Route Max duration Details
abiraterone 500 mg Once daily oral administration
Instructions:

Dosing is for micronised abiraterone (Yonsa®) only.

  • Swallow whole, may be taken either with or without food.
  • Monitor blood pressure at least once a month during treatment; for patients with hypertension monitor blood pressure every 2 weeks for the first 3 months of treatment.
methylprednisolone 4 mg Once daily oral administration
Instructions:
  • Take with food.
  • Do not stop taking this medicine without consulting your doctor.

Supportive Care Factors

No supportive care factors specified

References

Goldwater R, Hussaini A, Bosch B, Nemeth P. Comparison of a Novel Formulation of Abiraterone Acetate vs. the Originator Formulation in Healthy Male Subjects: Two Randomized, Open-Label, Crossover Studies. Clin Pharmacokinet. 2017 Jul;56(7):803-813., PMID: 28425029

Hussaini A, Olszanski AJ, Stein CA, Bosch B, Nemeth P. Impact of an alternative steroid on the relative bioavailability and bioequivalence of a novel versus the originator formulation of abiraterone acetate. Cancer Chemother Pharmacol. 2017 Sep;80(3):479-486., PMID: 28695267

Fizazi K, Tran N, Fein L, Matsubara N, Rodriguez-Antolin A, Alekseev BY, Özgüroğlu M, Ye D, Feyerabend S, Protheroe A, De Porre P, Kheoh T, Park YC, Todd MB, Chi KN; LATITUDE Investigators. Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer. N Engl J Med. 2017 Jul 27;377(4):352-360. , PMID: 28578607

Stein CA, Levin R, Given R, Higano CS, Nemeth P, Bosch B, Chapas-Reed J, Dreicer R. Randomized phase 2 therapeutic equivalence study of abiraterone acetate fine particle formulation vs. originator abiraterone acetate in patients with metastatic castration-resistant prostate cancer: The STAAR study. Urol Oncol. 2018 Feb;36(2):81.e9-81.e16. , PMID: 29150328

Chapas-Reed J, Stein C, Squittieri N, Concepcion R. One-Year, Open-Label Extension Study on the Safety and Efficacy of Abiraterone Acetate Fine Particle Formulation in Patients With Metastatic Castration-Resistant Prostate Cancer. Clinical Medicine Insights: Urology. 2020 Mar; 13:1-7.

James ND, de Bono JS, Spears MR et al; STAMPEDE Investigators. Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy. N Engl J Med. 2017 Jul 27;377(4):338-351. , PMID: 28578639

CARSL Consulting. YONSA MPRED abiraterone acetate and methylprednisolone New Zealand Data Sheet. 30 May 2024. https://www.medsafe.govt.nz/profs/datasheet/y/YonsaMpredtab.pdf (Accessed 05 Nov 2024).

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.