Systemic Anti-Cancer Therapy Regimen Library
GU PROS Castration resistant Metastatic - cabazitaxel Q3W and prEDNISone
Treatment Overview
Cycle 1 (and all further cycles) - 21 days
At the clinician’s discretion, prEDNISone may be given as 10 mg once daily (or equivalent corticosteroid dose).
Cycle details
Cycle 1 (and all further cycles) - 21 days
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| dexamethasone * | 8 mg | oral administration | 1 | |
| loratadine * | 10 mg | oral administration | 1 | |
| famotidine * | 20 mg | oral administration | 1 | |
| cabazitaxel | 20 mg/m² | intravenous | 1 | 60 minutes |
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration | 1 to 21 | |
| domperidone | 10 mg Three times daily | oral administration | 1 | |
| loperamide | 2 mg | oral administration | 1 |
At the clinician’s discretion, prEDNISone may be given as 10 mg once daily (or equivalent corticosteroid dose).
Full details
Cycle 1 (and all further cycles) - 21 days
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| dexamethasone * | 8 mg | oral administration |
Instructions:
ONE hour prior to chemotherapy with food. |
|
| loratadine * | 10 mg | oral administration |
Instructions:
ONE hour prior to chemotherapy. |
|
| famotidine * | 20 mg | oral administration |
Instructions:
ONE hour prior to chemotherapy. Do not take indigestion remedies, iron or calcium preparations within 2 hours of taking this medicine. |
|
| cabazitaxel | 20 mg/m² | intravenous | 60 minutes |
Instructions:
Prepare solution in PVC-free bag and administer via polyethylene lined administration set with an in-line filter of 0.22 microns or less in size. Please carry out graded challenge as per institutional policy. |
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
|
| domperidone | 10 mg Three times daily | oral administration |
Instructions:
When required for nausea and/or vomiting. |
|
| loperamide | 2 mg | oral administration |
Instructions:
Take TWO capsules (=4 mg) at onset of loose bowel motions and a further ONE capsule (=2 mg) for every loose bowel motion (maximum of EIGHT capsules in 24 hours), or use as directed by oncologist or haematologist. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 8
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 9
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 10
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 11
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 12
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 13
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 14
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 15
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 16
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 17
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 18
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 19
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 20
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Day: 21
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| prEDNISone * | 5 mg flat dosing Twice daily | oral administration |
Instructions:
Take with food. Do not stop taking this medicine without consulting your doctor. |
Supportive Care Factors
| Factor | Value |
|---|---|
| Diarrhoea risk: | Anti-diarrhoeals are usually prescribed with this treatment |
| Emetogenicity: | Low |
| Hypersensitivity / Infusion related reaction risk: | High - routine premedication recommended |
References
1. de Bono, J.S., A-C. Hardy-Bessard, C-S. Kim, et al. 2016. "Phase III non-inferiority study of cabazitaxel (C) 20mg/m2 (C20) versus 25mg/m2 (C25) in patients with metastatic castration resistant prostate cancer (mCRPC) previously treated with docetaxel (D). J Clin Oncol 34,2016 (suppl; abstr 5008).
3. Sanofi-Aventis U.S. LLC. Jevtana United States Prescribing Information March 2020. http://products.sanofi.us/Jevtana/Jevtana.html (Accessed 30 November 2020)
* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.