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Home > PCN MM - lenalidomide maintenance following LenBorDex lite

PCN MM - lenalidomide maintenance following LenBorDex lite

Treatment Overview

Lenalidomide maintenance continues after LenBorDex lite induction at the clinicans discretion.

See PCN MM - LenBorDex lite [lenalidomide, bortezomib, and dexamethasone] induction.

Cycle 1 (and all further cycles) - 28 days

Cycle length:
28

lenalidomide: Consider dose reduction of lenalidomide to 10 mg orally ONCE daily on days 1 to 21 if tolerance is of concern.

Cycle details

Cycle 1 (and all further cycles) - 28 days

Medication Dose Route Days Max Duration
lenalidomide * 15 mg Once daily oral administration 1 to 21

lenalidomide: Consider dose reduction of lenalidomide to 10 mg orally ONCE daily on days 1 to 21 if tolerance is of concern.

Full details

Cycle 1 (and all further cycles) - 28 days

Day: 1

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 2

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 3

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 4

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 5

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 6

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 7

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 8

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 9

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 10

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 11

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 12

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 13

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 14

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 15

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 16

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 17

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 18

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 19

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 20

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Day: 21

Medication Dose Route Max duration Details
lenalidomide * 15 mg Once daily oral administration
Instructions:
  • Take each dose on an empty stomach—at least one hour before OR two hours after food.
  • Swallow whole, do not crush or chew.
  • Consider dose reduction to 10 mg if tolerance is of concern.
Additional details:

Additional details

Section 1: Teratogenic effects

All patients must fulfil the requirements of the pregnancy prevention risk management programme to ensure pregnant women are not exposed to lenalidomide.

Supportive Care Factors

Factor Value
Antiviral prophylaxis for herpes virus: Routine antiviral prophylaxis may be considered
Emetogenicity: Minimal to low
Thromboprophylaxis: Thromboprophylaxis is recommended

Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.

References

Durie BGM, Hoering A, Abidi MH, et al. Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet. 2017 Feb 4;389(10068):519-527. , PMID: 28017406

O'Donnell EK, Laubach JP, Yee AJ, et al. A phase 2 study of modified lenalidomide, bortezomib and dexamethasone in transplant-ineligible multiple myeloma. Br J Haematol. 2018 Jul;182(2):222-230. , PMID: 29740809

Viatris Ltd. Lenalidomide New Zealand Medicine Data Sheet 11 August 2025. https://www.medsafe.govt.nz/profs/datasheet/l/LenalidomideViatriscap.pdf (Accessed 26 February 2026).

Regimen details sometimes vary slightly from the published literature after recommendation by expert committee consensus.

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.